AURONI DEEP
INVESTIGATING THE TRANSIENT STRUCTURES IN OUR GENOME
Auroni this side. I am currently pursuing my PhD from Kusuma School of Biological Sciences, IIT Delhi and was awarded the Prime Minister's Research Fellowship in the Cycle 11 lateral entry scheme.
I am presently trying to study the role of non-canonical DNA secondary structures in the physiological state of Hypoxia and my favorite hobby is to constantly look at my colorful CD curves until inferences pop up.
Hey!
Meet the Supervisors
Prof. Vivekanandan Perumal
Virology Lab, KSBS, IIT Delhi
Prof. Saran Kumar
Vascular Biology Lab, KSBS, IIT Delhi
AREAS OF INTEREST
intercalated Motifs (iMs)
As we progressively shift our focus towards non-canonical DNA secondary structures, an understanding of their physiological significance becomes essential. One such structure is the i-motif or the cytosine-tetrad. i-Motifs are intercalated constructions formed by hemiprotonated cytosine-cytosinium base pairs. The nuclear formation of C-Quadruplexes Read more...
Cancer and the Tumor Microenvironment
Cancer is a favorite of contemporary biologists, cancer plasticity being at the heart of present-day Oncology research. A major contributor to this plasticity is the Tumor Microenvironment that is also known to confer the much infamous drug resistance to cancer cells, hence making it a topic of utmost medical significance.
Hypoxia
While Oxygen is very often considered a primary requirement for supporting higher order living organisms, it is also an element that, in theory, makes life highly improbable. Free Radical Chemistry of Ageing, by Denham Harman, is one of the most revered theory of ageing based on the concept of oxidative damage, thus supporting the prior statement. At the same time, a state Read more...
Gallery
A glimpse into my PhD...
